Endocrine Abstracts

Background: Considerable overlap of IGF-I levels exists between normal subjects and those with severe GHD determined by conventional testing of GH status. Recognised factors influencing IGF-I status in GHD patients include age, gender, timing of onset of GHD and exogenous oestrogen therapy, but these do not fully explain the GH/IGF-I discordance in severe GHD. The primary structures of prolactin and GH are similar. Effects of hypoprolactinaemia are not well described in humans...